SNAP23 (NM 130798) Humaan Recombinant eiwit

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human synaptosomal-associated protein, 23kDa (SNAP23), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

HsT17016; SNAP-23; SNAP23A; SNAP23B

8773

O00161, A0A024R9R8, A8K287

NM_130798

15q15.1-q15.2

E. coli

N-GST and C-His

SNARE interactions in vesicular transport

SNARE interactions in vesicular transport

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome

45.6 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

SNAP23

Human

NP_570710

https://www.ncbi.nlm.nih.gov/gene/8773

https://www.uniprot.org/uniprot/O00161

https://www.ncbi.nlm.nih.gov/nuccore/NM_130798

https://www.ncbi.nlm.nih.gov/nuccore/NP_570710