SNCA Antilichaam

Alpha-Synuclein (SNCA) is a hallmark of Alzheimer's disease (1,2) . It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2) . SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3) . Defects in SNCA are associated with familial Parkinson's disease (4,5) .

6622

P37840

NP_000336

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience, Apoptosis

SNCA antibody is affinity chromatography purified via peptide column.

Cat. No. 1412 - Mouse Cerebellum Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%)

SNCA antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SNCA antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.

SNCA

Synuclein, alpha (non A4 component of amyloid precursor)

Homo sapiens

Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 1993; 90:11282-6.

Pronin AN, Morris AJ, Surguchov A, et al. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 2000; 275:26515-22.

Oaks AW, Frankfurt M, Finkelstein DI, et al. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS One 2013; 8:e60378.

Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997; 276:2045-7.

SNCA Antibody: PD1, NACP, PARK1, PARK4, Alpha-synuclein, Non-A beta component of AD amyloid

ELISA, WB, IHC-P, IF

6806898

Liquid