SNCA Antilichaam [2B2D1 / 2B2A11]

Alpha-synuclein (SNCA), with 140-amino acid protein (about 15 kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver) . SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.

6622

P37840

P37840

Human

Ni-NTA purified truncated recombinant SNCA expressed in E. Coli strain BL21 (DE3) .

2B2D1 / 2B2A11

Unconjugated

Primary Antibodies

Neuroscience

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

SNCA monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

SNCA

Synuclein, alpha (non A4 component of amyloid precursor)

Homo sapiens

J. Johnson, S. M. Hague, M. Hanson. Neurology, Aug 2004; 63: 554 – 556.

Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie. Protein Pept Lett. 2006;13 (4) :385-90.

NACP, PARK1, Non-A beta component of AD amyloid, NACP, PD1, PARK4

ELISA, WB, IHC

586067