SnoN Antilichaam

SnoN Antibody: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN; SnoN antibody will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA) .

6498

P12757

NP_005405

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction, Cancer

SnoN Antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 - A431 Cell Lysate

1 mg/ml

SnoN Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SnoN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SKIL

Cat. No. 1402 - Mouse Lung Tissue Lysate

SKI-like oncogene

Homo sapiens

Derynck R, Akhurst RJ, and Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 2001; 29:117-129.

Li Y, Turck CM, Teumer JK, et al. Unique sequence, Ski, in Sloan-Kettering avian retrovirus with properties of a new cell-derived oncogene. J. Virol. 1986; 57:1065-72.

Luo K. Ski and SnoN: negative regulators of TGF-β signaling. Curr. Op. Gen. Dev. 2004; 14:65-70.

Massague J and Wotton D. Transcriptional control by the TGF-β /Smad signaling system. EMBO J. 2000; 19:1745-54.

SnoN Antibody: SNO, SnoA, SnoI, SnoN, SNO, Ski-like protein, Ski-related oncogene

ELISA, WB, IHC-P, IF

223029418

Liquid