SOCS7 Antilichaam - N-terminaal gebied: Biotine (ARP53701 P050-Biotine)

Suppressor of cytokine signaling 7

NAP4, NCKAP4

30837

O14512-2

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N-terminal region of Human SOCS7

SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. It functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. It inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

SEPT6; SORBS3; STAT5A; STAT3; CUL5; IRS4; PIK3R2; TUBB4B; TUBA1A; IRS2; NCK1; PLCG1; PIK3R1; EGFR; GRB2

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 92%; Guinea Pig: 83%; Horse: 100%; Human: 100%; Mouse: 85%; Pig: 92%; Rabbit: 100%; Rat: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

36kDa

Wet Ice

331

SOCS7

SOCS7

Rabbit

Suppressor of cytokine signaling 7

GSAGRELDAGRKPKLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTS