SOGA1 Antilichaam

The recently identified protein suppressor of glucose by autophagy protein 1 (SOGA1) has been found to be involved in the regulation of autophagy (1) . SOGA1 is thought to contribute to adiponectin-mediated insulin-dependent inhibition of autophagy during the activation of adenosine monophosphate kinase (AMPK) (1,2) . SOGA1 contains an internal signal peptide that enables the secretion of a circulating fragment of SOGA1, providing a surrogate marker for intracellular SOGA1 levels (2) . Knockdown of SOGA1 elevated glucose production in primary hepatocytes indicates that SOGA1 is an inhibitor of glucose production. It thus might be useful as a novel therapeutic target for diabetes (3) .

140710

O94964

NP_954650

Human

Unconjugated

Primary Antibodies

Autophagy

SOGA1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (93%)

SOGA1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SOGA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SOGA1 antibody is human specific. At least four isoforms of SOGA1 are known to exist.

SOGA1

Cat. No. 17-001 - HeLa Cell Slide

Suppressor of glucose, autophagy associated 1

Homo sapiens

Cowherd RB, Asmar MM, Alderman JM, et al. Adiponectin lowers glucose production by increasing SOGA. Am. J. Pathol. 2010; 177:1936-45.

Madi T, Balamurugan K, Bombardi R, et al. The determination of tissue-specific DNA methylation patterns in forensic biofluids using bisulfite modification and pyrosequencing. Electrophoresis 2012; 33:1736-45.

Forbes JM. The physiological deadlock between AMPK and gluconeogenesis: SOGA, a novel protein, may provide the key. Am. J. Pathol. 2010; 177:1600-2.

SOGA1 Antibody : SOGA, KIAA0889, C20orf117, SOGA, Protein SOGA1, SOGA family member 1, 80-kDa SOGA fragment

ELISA, WB, IF

66773344

Liquid