Sorafenib (basis)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM) ; VEGFR-2 (IC50 = 90 nM) ; VEGFR-3 (IC50 = 20 nM) ; PDGFR-β (IC50 = 57 nM) ; Flt3 (IC50 = 58 nM) ; c-KIT (IC50 = 68 nM) ; FGFR-1 (IC50 = 580 nM) 1. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms2. Inhibits activation of MAPK pathway and ERK phosphorylation3. Induces caspase-independent apoptosis in melanoma cells4. Clinically useful anticancer agent.
Unconjugated
Off-white solid
-20°C
Beschrijving
Sorafenib (basis) Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
Specificaties
Recent bekeken producten
Cellubrevin Antibody
MBS9436639-01
0.05 mL
Oxidative Stress Combo Assay Tissue Kit
EA-7008
1 Each
Arachis hypogaea Lectin (PNA) - Biotinylated
21510020-1
5mg
1,4- Dioxane Pure
1041330 500
500 mL
Benzonase ELISA Kit
EG23601S
96 Tests
Not I Restriction Enzyme
B2016623
500 Units
K562-HLA-G0101 Overexpressing Cell Line
RG-1214
5x 10^6
Yeast Poly (A) Polymerase
RNT-006-S
30000 Units
Recent gezochte producten
Cellubrevin Antibody
MBS9436639-01
0.05 mL
Rat Oxidative Stress Primer Library
ROSL-I
1 set
DTNB (Ellman’s) Thiol Oxidative Stress Assay
1021
1 Kit
OSR1 (Oxidative Stress Responsive 1)
MBS616581-01
0.1 mL
Oxidative Stress Combo Assay Cell Kit
EA-7006
1 Each
Oxidative Stress Combo Assay Blood Kit
EA-7007
1 Each
Oxidative Stress Combo Assay Tissue Kit
EA-7008
1 Each
OSR1 (Oxidative Stress Responsive 1)
O8054
100 µL