SORL1 Antilichaam [3B6A9 / 3B6B11]

SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein) . SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

6653

Q92673

Q92673

Human

Purified truncated recombinant SORL1-MBP expressed in E. Coli strain BL21 (DE3) .

3B6A9 / 3B6B11

Unconjugated

Primary Antibodies

Neuroscience

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

SORL1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

SORL1

Sortilin-related receptor, L (DLR class) A repeats containing

Homo sapiens

Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61 (8) :1200-5.

Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13 (4) :649-52.

Shah S. Yu G. Mol Interv. 2006, Apr, 6 (2) :74-6, 58. Review.

C11orf32, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, LR11, LRP9, SORLA, gp250, SorLA-1, C11orf32

ELISA, WB, IHC

296452912