SOX10 Antilichaam

SOX10 Antibody: SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of the cell fate (1) . The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins (2) . This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development (2) . Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschprung disease (3) . SLC30A8 expression in beta-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4) .

6663

P56693

NP_008872

Human, Mouse, Rat

SOX10 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human SOX10.

Unconjugated

Primary Antibodies

Signal Transduction, Stem Cell

SOX10 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1461 - Rat Heart Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%), Chicken: (89%), Goat: (100%)

SOX10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SOX10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SOX10 Antibody is predicted to not cross-react with other SOX familiy members.

SOX10

SRY-box 10

Homo sapiens

Pusch C, Hustert E, Pfeifer D, et al. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum. Genet. 1998; 103:115-23.

Rehberg S, Lischka P, Glaser G, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol. Cell Biol. 2002; 22:5826-34.

Pingault V, Bondurand N, Kuhlbrodt K, et al. SOX10 mutations in patients with Waardenburg-Hirschprung disease. Nat. Genet. 1998; 18:171-3.

SOX10 Antibody: SRY (sex determining region Y) -box 10, DOM, WS4, PCWH, WS2E, WS4C

ELISA, WB, IHC-P, IF

5902104

Liquid