SOX18 Antilichaam

SOX18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2) . SOX18 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types (3) . SOX is known to be involved with vascularization and endothelial development, suggesting that it may be useful as a potential target for inhibiting tumor angiogenesis (4) . Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia (5) .

54345

P35713

NP_060889

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

SOX18 antibody is affinity chromatography purified via peptide column.

Cat. No. 1212 - 3T3 Cell Lysate

1 mg/mL

SOX18 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SOX18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SOX18 antibody is human, mouse and rat reactive. SOX18 is predicted to not cross-react with other SOX proteins.

SOX18

RY (sex determining region Y) -box 18

Homo sapiens

Dunn TL, Mynett-Johnson L, Wright EM, et al. Sequence and expression of Sox-18 encoding another HMG-box transcription factor. Gene 1995; 161:223-5.

Jiang T, Hou CC, She ZY, et al. The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol. Biol. Rep. 2013; 40:2187-94.

Francois M, Koopman P, and Beltrame M. SoxF genes: key players in the development of the cardiovascular system. Int. J. Biochem. Cell Biol. 2010; 42:445-8.

Young N, Hahn CN, Poh A, et al. Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. J. Natl. Cancer Inst. 2006; 98:1060-7.

SOX18 Antibody: HLTS, Transcription factor SOX-18

ELISA, WB

8924248

Liquid