SOX4 Antilichaam

SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate (1,2) . It may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin) (3) . SOX4 contains one HMG box DNA-binding domain and may function in the apoptosis pathway leading to cell death. It has also been suggested to play a role in tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development (4,5) .

6659

Q06945

NP_003098

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Apoptosis

SOX4 antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

SOX4 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SOX4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SOX4 antibody is human, mouse and rat reactive.

SOX4

SRY (Sex determining region Y) -box 4

Homo sapiens

Wotton D, Lake RA, Farr CJ, et al. The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer. J. Biol. Chem. 1995; 270:7515-22.

Pan X, Li H, Zhang P, et al. Ubc9 interacts with SOX4 and represses its transcriptionalactivity. Biochem. Biophys. Res. Commun. 2006; 344:727-34.

Castillo SD, Matheu A, Mariani N, et al. Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer. Cancer Res. 2012; 72:176-86.

Zhang H, Alberich-Jorda M, Amabile G, et al. Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia. Cancer Cell 2013; 24:575-88.

SRY (Sex determining region Y) -box 4, Transcription factor SOX-4, EVI16

ELISA, WB, IHC-P, IF

4507163

Liquid