SP100030
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SP100030 is a potent dual inhibitor of NF-kB- and AP-1-mediated gene expression (IC50’s = 50 nM for both in transfected Jurkat T-cells) .1 It was able to specifically block IL-2 and IL-8 in Jurkat T-cells (IC50’s = 30 nM for both) .1 SP100030 treatment significantly decreased arthritis severity in DBA/1J mice.2 It selectively inhibited CD8 (+) T-cells and mRNA expression of TH1 and Th2 cytokines in a rat model of asthma but did not inhibit allergen-induced eosinophilia and bronchial hyperresponsiveness.3 SP100030 ameliorated muscle wasting in a cancer cachexia rat model.4 SP100030 suppression of T cell activation has been attributed to targeting of XPO1 (with minimal impact on nuclear export and cell viability) .5
Unconjugated
Off-white solid
-20°C
Beschrijving
SP100030 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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