Sp4 Antibody Picoband® fluoro488 Vervoeging

SP4 (Sp4 transcription factor), also known as Transcription factor Sp4, MGC130008, MGC130009, SPR-1, HF1B,   is a  protein  that in humans is encoded by the  SP4  gene. It is a multigene family of SP proteins. Northern blot analysis that SP4 is abundantly expressed as a 7.5-kb message in brain, but barely detectable in other human cell lines. SP4 is an activator protein like SP1. However, in contrast to SP1, SP4 is not able to act synergistically through adjacent binding sites.

Transcription factor Sp4; SPR-1; SP4

SP4

6671

Q02446

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human SP4, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Abundant in brain.

Flow Cytometry

Cancer, Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

1. Hagen, G., Muller, S., Beato, M., Suske, G. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res. 20: 5519-5525, 1992. 2. Hagen, G., Dennig, J., Preiss, M., Beato, M., Suske, G.Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. J. Biol. Chem. 270: 24989-24994, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

81985 MW

No cross reactivity with other proteins.

6

Transcription factor Sp4

Nucleus.

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Transcription factor Sp4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.