SP600125
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
129-56-6
Nsc75890
C07815-10mg
JNK
MAPK
C1=CC=C2C (=C1) C3=NNC4=CC=CC (=C43) C2=O
C14H8N2O
SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A, FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.
2 years -80 in solvent
Beschrijving
SP600125 Beschikbaar in 10 mg. Wordt geleverd met droogijs. Bestel eenvoudig online met snelle levering.
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