SPDI-48-T1

SPDI-48-T1 is a lysine-stapled peptide. SPDI-48-T1 exhibits discernible binding affinities for MDM2 and MDMX, with Kd values of 396 nM and 456 nM, respectively. SPDI-48-T1 exhibits anticancer activity against breast cancer, colorectal cancer, non-small cell lung cancer, cervical cancer, and malignant melanoma[1].

12352209

MDM-2/p53

Apoptosis

Cancer-programmed cell death

Cancer

O=C(C)N[C@H](C(N[C@@H](C(C)O)C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(N[C@@H](CCCCNC3)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)C)=O)CO)=O)C(O)C)=O)=O)CCC(N)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)CCCCNCC6=CC=CC3=C6)=O)CC7=CC=CC=C7)=O)=O)CC(C)C

C91H129N21O20

1837.13

[1]Xu L, et al. Design, Synthesis, and Biological Evaluation of Lysine-Stapled Peptide Inhibitors of p53-MDM2/MDMX Interactions with Potent Antitumor Activity In Vivo. J Med Chem. 2024 Oct 10;67 (19) :17893-17904.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11255/

Peptides

No Development Reported