Spermine-d8 (tetrahydrochloride)

Spermine-d8 (tetrahydrochloride) is the deuterium labeled Spermine tetrahydrochloride. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells[1][2][3][4][5][6][7].

1173022-85-9

12352211

H318

Bacterial; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Metabolic Disease

95.0

10 mM in DMSO

NCCCNC(C(C(C(NCCCN)([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H].Cl.Cl.Cl.Cl

C10H22D8Cl4N4

356.23

H318

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]U. Bachrach & B. Reches, (1966) Enzymic assay for spermine and spermidine, Analytical Biochemistry, Volume 17, Issue 1, Volume 17, Issue 1, ISSN 0003-2697.|[3]WANG Jing, et al., (2022) Preliminary Study on Spermine Tetrahydrochloride Inhibition of Platelet Activation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24 (3) : 315-319.|[4]Byrd, W. J., et al., (1977) . Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature, 267 (5612), 621–623. |[5]Dawson, M., & Dryden, W. F. (1969) . The toxicity of spermine and spermidine to cells in culture. Biochemical pharmacology, 18 (6), 1307–1313.|[6]Løvaas, E., & Carlin, G. (1991) . Spermine: an anti-oxidant and anti-inflammatory agent. Free radical biology & medicine, 11 (5), 455–461.|[7]Otsuki, M., et al., (1995) . In vivo pharmacological study of spermine-induced neurotoxicity. Neuroscience letters, 196 (1-2), 81–84.

Blue Ice

-20°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-B1777AS/Spermine-d8-tetrahydrochloride-SDS-MedChemExpress.pdf

Isotope-Labeled Compounds

No Development Reported