SPI1 Antilichaam - middengebied: HRP (ARP38241 P050-HRP)

Spleen focus forming virus (SFFV) proviral integration oncogene spi1

OF, PU.1, SFPI1, SPI-1, SPI-A

6688

P17947

NP_003111

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human SPI1

SPI1 is known to collaborate with multiple transcription factors and to regulate expression of immunoglobulin genes. Lack of SPI1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.

HOXA10; TMX1; VAV1; IRF1; IRF8; GATA3; GATA2; GATA1; GFI1; TBP; RB1; BYRF1; RARA; PML; HDAC3; SKI; SIN3A; HDAC1; BCL6; CEBPA; PIP; SPIB; SSRP1; IRF4; KAT6A; CEBPE; NFATC1; CREBBP; NONO; CEBPB; JUN; ERG; NFKB1; MITF; FUS; CREM; ATF1; CEBPD; MECP2; DNMT3B

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

31kDa

Crotti, T.N., (2008) J. Cell. Physiol. 215 (3), 636-644

Wet Ice

270

SPI1

SPI1

Rabbit

Transcription factor PU.1

NM_003120

QKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAER