SPIB Antilichaam

SPIB is a member of the ETS transcription factor family that influences lymphoid development and activity and binds the consensus DNA site GGA (A/T) through a unique winged helix-turn-helix motif known as the ETS domain (1) . SPIB is found in hematopoietic cells such as B cells and plasmacytoid dendritic cells (DC) (2,3) . It promotes the development of plasmacytoid dendritic cells (pDCs) or natural interferon (IFN) -producing cells. SPIB may be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation (3,4) .

6689

Q01892

NP_003112

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Immunology

SPIB antibody is affinity chromatography purified via peptide column.

Cat. No. 1312 - Human Prostate Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (88%)

SPIB antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SPIB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SPIB antibody is human, mouse and rat reactive. At least four isoforms of SPIB are known to exist; this antibody will detect all but isoform 3.

SPIB

Spi-B transcription factor (Spi-1/PU.1 related)

Homo sapiens

Ray D, Bosselut R, Ghysdael J, et al. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol. Cell Biol. 1992; 12:4297-304.

Nagy M, Chapuis B, and Matthes T. Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. Br. J. Haematol. 2002; 116:429-35.

Schotte R, Rissoan MC, Bendriss-Vermare N, et al. The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. Blood 2003; 101:1015-23.

Schotte R, Nagasawa M, Weijer K, et al. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J. Exp. Med. 2004; 200:1503-9.

Spi-B transcription factor, SPI-B

ELISA, WB, IHC-P, IF

61888836

Liquid