SPINK2 Antilichaam

SPINK2 Antibody: Human serine proteinase inhibitor Kazal-type 2 (SPINK2) is required for maintaining normal spermatogenesis and potentially regulates serine protease-mediated apoptosis in male germ cells. It contains a typical kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. SPINK2 plays a role in the pathogenesis of hereditary and chronic pancreatitis.

69982

Q8BMY7

NP_001276693.1

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

SPINK2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%)

SPINK2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SPINK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SPINK2 antibody is predicted to not cross-react with other SPINK family members.

SPINK2

Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)

Mus musculus

Lee B, Park I, Jin S, et al. Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes. J. Biol. Chem. 2011; 286:29108-17

Chen T, Lee TR, Liang WG, et al. Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor. Proteins 2009; 77:209-19.

Liddle RA. Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol. Metab. Clin. North Am. 2006; 35:345-56.

SPINK2 Antibody: HUSI-II, Serine protease inhibitor Kazal-type 2, Acrosin-trypsin inhibitor

ELISA, WB, IHC-P, IF

576796017

Liquid