SPINSTER Antilichaam

SPINSTER, also known as SPNS1 or SPIN1, is a 528 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and belongs to the spinster subfamily of the major facilitator superfamily (1) . SPINSTER interacts with Bcl-x and Bcl-2 and, via this interaction, is thought to be involved in necrotic or autophagic cell death (2) . The related protein SPNS2 is critical for the normal lymphocyte localization and mammalian immune system function (1,3) .

83985

Q9H2V7

NP_001135920

Human

Unconjugated

Primary Antibodies

Autophagy

SPINSTER antibody is affinity chromatography purified via peptide column.

Cat. No. 1211 - HepG2 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (83%), Rat: (81%), Mouse: (81%)

SPINSTER antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SPINSTER antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SPINSTER antibody is human specific. At least four isoforms of SPINSTER are known to exist. This antibody is predicted to not cross-react with other members of the spinster family of proteins.

SPNS1

Cat. No. 1309 - Human Placenta Tissue Lysate

Cat. No. 10-101 - Human Lung Tissue Slide

Spinster homolog 1 (Drosophila)

Homo sapiens

Saier MH Jr, Beatty JT, Goffeau A, et al. The major facilitator superfamily. J. Mol. Microbiol. Biotechnol. 1999; 1:257-79.

Yanagisawa H, Miyashita T, Nakano Y, et al. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ. 2003; 10:798-807.

Nakano Y, Fujitani K, Kurihara J, et al. Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster. Mol. Cell. Biol. 2001; 21:3775-88.

SPINSTER Antibody: LAT, nrs, SPIN1, SPINL, HSpin1, PP2030, PP20300, Protein spinster homolog 1

ELISA, WB, IHC-P, IF

215490098

Liquid