SPOP Antibody - C-terminal regio : HRP (ARP50348_P050-HRP)

Speckle-type POZ protein

TEF2, BTBD32, NSDVS1, NSDVS2, NEDMACE, NEDMIDF

8405

O43791

NP_001007227

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human SPOP

SPOP may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

CUL3; SPOP; DEK; GLI2; AR; ATM; RXRB; MYD88; DAXX; NCOA3; SRRM1; GIT2; FADD; PIAS1; UBC; UBE2E3; PIP4K2B; ESR1; BMI1; RTN3; H2AFY; DPPA2; ZBTB16; HCST; TRAF1; PDX1; DDIT3; TRAF6; SIRT2; DOK2; PIP5K1B; GDI1; KPNA6

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

SPOP is supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

42kDa

Bunce, M.W., (2008) J. Biol. Chem. 283 (13), 8678-8686

Wet Ice

374

SPOP

SPOP

Rabbit

Speckle-type POZ protein

NM_001007226

YHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS