SPP1 Antilichaam

SPP1 Antibody: The secreted protein 1 (SPP1), also known as osteopontin, is a major noncollagenous protein of bone, but is also found in the extracellular matrix of other mineralized tissues and in bodily fluids. In bone, SPP1 is produced by osteoblasts, osteocytes, macrophages, and osteoclasts (1,2) . SPP1 binds to cells through integrin and non-integrin receptors, as well as the adhesion receptor CD44 in an RGD-independent manner, enabling SPP1 to induce a number of functional effects including macrophage chemotaxis, cytoprotection, and regulation of T helper type 1 cells (2) . SPP1 can regulate biomineralization by inhibiting the formation of hydroxyapatite (3) and the growth of calcium oxalate crystals (4) .

6696

P10451

NP_001238759

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

SPP1 Antibody is Protein A purified.

Cat. No. 1310 - Human Bladder Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (94%), Bovine: (83%)

SPP1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SPP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SPP1 antibody is human, mouse and rat reactive. Multiple isoforms of SPP1 are known to exist.

SPP1

Secreted phosphoprotein 1

Homo sapiens

Heinegard D, Andersson G, and Reinholt FP. Roles of osteopontin in bone remodeling. Ann. N.Y. Acad. Sci.1995; 760:213-22.

Wang KX and Denhardt DT. Osteopontin: rule in immune regulation and stress responses. Cyto. Growth Factor Rev. 2008; 19:333-45.

Boskey AL, Maresca M, Ullrich W, et al. Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel. Bone Miner. 1993; 22:147-159.

Shiraga H, Min W, VanDusen WJ, et al. Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. Proc. Natl. Acad. Sci. USA 1992; 89:426-30.

SPP1 Antibody: OPN, BNSP, BSPI, ETA-1, OPN, PSEC0156, Osteopontin, Bone sialoprotein 1, SPP-1

ELISA, WB, IHC-P, IF

352962176

Liquid