SR-1001
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
A high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity1. It inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model3. Protects against pathologic neovascularization in various mouse models of retinopathy4. Active in vivo
Unconjugated
Cream-colored solid
-20°C
Beschrijving
SR-1001 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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