SR 47063
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SR 47063 is an ATP-sensitive potassium channel (KATP) agonist. SR 47063 selectively activates KATP channels in vascular smooth muscle cells (IC50: 8.1 nM in human saphenous vein, 3.86 nM in rat aorta) . SR 47063 promotes potassium efflux and cellular hyperpolarization to induce vasorelaxation. SR 4706 is promising for research of hypertension and related cardiovascular disorders[1].
135809-60-8
12352005
Potassium Channel
Membrane Transporter/Ion Channel
Cardiovascular Disease
N#C/N=C1C=CC=CN\1C2=CC(C)(C)OC3=C2C=C([N+]([O-])=O)C=C3
C17H14N4O3
322.32
[1]Criddle DN, et al. Vasorelaxant effects of the potassium channel opener SR 47063 on the isolated human saphenous vein and rat aorta. Braz J Med Biol Res. 2000 Aug;33 (8) :961-6.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19138/
Reference compound1
Phase 1
Beschrijving
SR 47063 is an ATP-sensitive potassium channel (KATP) agonist. SR 47063 selectively activates KATP channels in vascular smooth muscle cells (IC50: 8.1 nM in hum
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