SRESF2 Antilichaam

The sterol regulatory element binding transcription factor 2 (SREBF2) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1,2) . The related protein SREBF1 also binds SRE1 and activates transcription in an additive fashion to SREBF2 (2) . SREBF2 has been more closely associated with cholesterol synthesis and accumulation, while the SREBF1 proteins are important in the regulation of genes involved in lipid metabolism (3) .

6721

Q12772

NP_004590

Human, Mouse

Unconjugated

Primary Antibodies

Obesity

SREBF2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1216 - PC-3 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%)

SREBF2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SREBF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SREBF2 antibody is human and mouse reactive. At least three isoforms of SREBF2 are known to exist. SREBF2 antibody is predicted not to cross-react with SREBF1.

SREBF2

Cat. No. 10-901 - Human Spleen Tissue Slide

Sterol regulatory element binding transcription factor 2

Homo sapiens

Hua X, Yokoyama C, Wu J, et al. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA 1993; 90:11603-7.

Wang X, Briggs MR, Hua X, et al. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. J. Biol. Chem. 1993; 268:14497-504.

Raghow R, Yellaturu C, Deng X, et al. SREBPs: the crossroads of physiological and pathological homeostasis. Endocrinol. Metab. 2008; 19:65-73.

SREBF2 Antibody: SREBP2, bHLHd2, SREBP-2, BHLHD2, SREBP2, Sterol regulatory element-binding protein 2, Class D basic helix-loop-helix protein 2

ELISA, WB, IHC-P, IF

27477113

Liquid