SRPK1 Antilichaam

SRPK1 and SRPK2, two Arginine/serine-rich (SR) protein-specific kinases constitute control circuits to regulate both constitutive and alternative pre-mRNA splicing and coordinate splicing with transcription in cells (1) . They are highly specific for the phosphorylation of these RS proteins, and highly expressed in testis (1,2) . SRPK1 plays a role in the condensation of sperm chromatin and controls the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis (3,4) .

6732

Q96SB4

NP_003128

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cell Cycle, Homeostasis

SRPK1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1404 - Mouse Liver Tissue Lysate

1 mg/mL

SRPK1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SRPK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SRPK1 antibody is human, mouse and rat reactive. Multiple isoforms of SRPK1 are known to exist; this antibody will detect all except isoforms b and e. SRPK1 antibody is predicted to not cross-react with SRPK2.

SRPK1

Cat. No. 11-701 - Human Testis Tissue Slide

SRSF protein kinase 1

Homo sapiens

Wang HY, Arden KC, Bermingham JR Jr, et al. Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Genomics 1999; 57:310-5.

Daub H, Blencke S, Habenberger P, et al. Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. J. Virol. 2002; 76:8124-37.

Zhong XY, Ding JH, Adams JA, et al. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 2009; 23:482-95.

Mavrou A, Brakspear K, Hamdollah-Zadeh M, et al. Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer. Oncogene 2014 Nov 10. doi: 10.1038/onc.2014.360.

SRSF protein kinase 1, Serine/arginine-rich protein-specific kinase 1, Serine/threonine-protein kinase SRPK1, SFRSK1, SR-protein-specific kinase 1

ELISA, WB, IHC-P

47419936

Liquid