SRPX2 Antilichaam

SRPX2 Antibody: Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.

27286

O60687

NP_055282

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer

SRPX2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1302 - Human Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

SRPX2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SRPX2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SRPX2

Cat. No. 10-101 - Human Lung Tissue Slide

Sushi-repeat-containing protein, X-linked 2

Homo sapiens

Roll P, Rudolf G, Pereira S, et al. SRPX2 mutations in disorders of language cortex and cognition. Hum. Mol. Genet.2006; 15:1195-207.

Miljkovic-Licina M, Hammel P, Garrido-Urbani S, et al. Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB J.2009; 23:4105-16.

Blasi F and Carmeliet P. uPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell. Biol.2002; 3:932-43.

Tanaka K, Arao T, Maegawa M, et al. SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion. Int. J. Cancer2009; 124:1072-80.

SRPX2 Antibody: BPP, CBPS, PMGX, RESDX, SRPUL, Sushi repeat-containing protein SRPX2, Sushi-repeat protein upregulated in leukemia

ELISA, WB, IHC-P, IF

7657619

Liquid