SRSF3 Antilichaam

SRSF3, a member of the serine/arginine (SR) -rich family of pre-mRNA splicing factors which constitute part of the spliceosome, may be involved in RNA processing in relation with cellular proliferation and/or maturation (1,2) . Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins (3) . The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation (3,4) .

6428

P84103

NP_003008

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Cancer

SRSF3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

SRSF3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SRSF3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SRSF3 antibody is human, mouse and rat reactive.

SRSF3

Serine/arginine-rich splicing factor 3

Homo sapiens

Sen S, Jumaa H, and Webster NJ. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat. Commun. 2013; 4:1336.

Gonçalves V, Matos P, and Jordan P. The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. RNA 2008; 14:2538-49.

Tang Y, Horikawa I, Ajiro M, et al. Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence. Oncogene 2013; 32:2792-8.

Jia R, Li C, McCoy JP, et al. SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance. Int. J. Biol. Sci. 2010; 6:806-26.

Serine/arginine-rich splicing factor 3, Pre-mRNA-splicing factor SRP20, SFRS3, Splicing factor arginine/serine-rich 3, SRP20

ELISA, WB, ICC, IF

4506901

Liquid