SRY Antilichaam - middelste regio : HRP (ARP34794_P050-HRP)

Sex determining region Y

TDF, TDY, SRXX1, SRXY1

6736

Q05066

NP_003131

Human

The immunogen is a synthetic peptide directed towards the middle region of human SRY

SRY is an intronless gene that encodes for a transcription factor, which is a member of the high mobility group (HMG) -box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome) ; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG) -box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome) ; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Olig2; Utf1; Tcf12; Sp1; Pou3f3; Pax3; Jun; Hhex; Egr2; Dlx5; Cebpa; WDR5; SMAD3; HDAC3; KPNB1; EP300; Xpo4; ZNF208; SLC9A3R2; AR

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

SRY is supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

24kDa

Queralt, R., (2008) Am. J. Med. Genet. A 146A (10), 1335-1340

Wet Ice

204

SRY

SRY

Rabbit

Sex-determining region Y protein

NM_003140

SEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL