SSB Antilichaam - N-terminaal gebied: Biotine (ARP40462_P050-Biotine)

Sjogren syndrome antigen B (autoantigen La)

La, LARP3, La/SSB

6741

P05455

NP_003133

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human SSB

SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III (see MIM 606007) -transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006) .[supplied by OMIM].

HUWE1; UBC; MDM2; LIN28A; BMI1; SUZ12; RNF2; rev; NPLOC4; DNM1L; UBA2; ANP32A; VBP1; RABGGTA; PPP2CA; KARS; CTTN; TARDBP; SOX2; HMGA1; ARFGEF1; NCL; GZMH; CSNK2B; CSNK2A1; HCVgp1; CBX6; SPIB; IL7R; IFIT3; FN1; SMURF1; BARD1; PAXIP1; APP; TROVE2; XIAP; CAN

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

SSB is strongly supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

45kDa

Teplova, M., (2006) Mol. Cell 21 (1), 75-85

Wet Ice

408

SSB

SSB

Rabbit

Lupus La protein

NM_003142

ISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWL