Ssm spooky toxine (TFA)

Ssm Spooky Toxin TFA is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC50s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin TFA inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin TFA plays an essential role in the centipede’s circulatory system[1] [2][3].

SsTx Toxin (TFA)

12352209

Potassium Channel

Membrane Transporter/Ion Channel

COVID-19-immunoregulation

Inflammation/Immunology; Neurological Disease

99.09

O=C([C@@H](N)CCC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N3[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]4CCCCN)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)=O)CCC3)=O)CCCCN)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CO)=O)CCC(O)=O)=O)CC(O)=O)=O)=O)=O)[C@@H](C)O)=O)CC7=CC=CC=C7)=O)CO)=O)[C@@H](C)O)=O)C)=O)CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CC9=CC=CC=C9)=O)CC%10=CC=C(O)C=C%10)=O)=O)C)=O)CCCCN)=O)CC(C)C)=O)CSSC[C@H](NC4=O)C(N[C@H]8[C@@H](C)O)=O)=O)CCC(O)=O)=O)CO)=O)CCCCN)=O)CC%11=CC=C(O)C=C%11)=O)CCC2)=O)CC%12=CC=CC=C%12)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CC%13=CC=C(O)C=C%13)=O)CCC1)=O)[C@@H](C)O)=O)CC(O)=O)=O)CCCCN)=O)CCCCN)=O)[C@H](CC)C)=O)C(C)C.O=C(O)C(F)(F)F.[x]

C270H413N69O79S4.xC2HF3O2

6017.84 (free base)

[1]Canwei Du, et al. Centipede KCNQ Inhibitor SsTx Also Targets KV1.3. Toxins (Basel) . 2019 Feb; 11 (2) : 76.|[2]Shilong Yang, et al. Target switch of centipede toxins for antagonistic switch. Sci Adv. 2020 Aug 7;6 (32) :eabb5734.|[3]Anna Luo, et al. Centipede Venom: A Potential Source of Ion Channel Modulators. Int J Mol Sci.2022 Jun 26;23 (13) :7105.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P5925A/Ssm-spooky-toxin-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported