SSR-181507 (hydrochloride)

SSR-181507 hydrochloride is a dopamine D2 receptor antagonist and 5-HT1A receptor agonist. SSR-181507 antagonizes Apomorphine -induced climbing in mice and stereotypies in rats. SSR-181507 hydrochloride can be used in the research of depression and anxiety[1].

223502-85-0

12352005

5-HT Receptor; Dopamine Receptor

GPCR/G Protein; Neuronal Signaling

Neurological Disease

ClC1=CC=C(OC[C@H](CNC[C@H]2C[C@@H]3CC[C@@H](N3C(C4=CC=CC=C4)=O)C2)O5)C5=C1.Cl

C24H28Cl2N2O3

463.40

[1]Depoortere R, et al. SSR181507, a dopamine D2 receptor antagonist and 5-HT1A receptor agonist. II: Behavioral profile predictive of an atypical antipsychotic activity. Neuropsychopharmacology. 2003 Nov;28 (11) :1889-902.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19372/

Reference compound1

Phase 1

5-HT1 Receptor; D2 Receptor