SSRP1 Antilichaam - middengebied: Biotine (ARP31141_P050-Biotine)

Structure specific recognition protein 1

FACT, T160, FACT80

6749

Q08945

NP_003137

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human SSRP1

SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. SSRP1 contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. It also functions as a co-activator of the transcriptional activator p63. The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

SUMO2; SUMO3; ATRX; UBC; EED; RNF2; SEC24C; CUL1; CSDE1; ATP6V1B2; DIABLO; SBNO1; PBDC1; EXOSC10; CSNK2A1; PNKP; VCAM1; SRPK1; ITGA4; FMNL1; SUPT16H; CENPA; LEO1; PAF1; PHGDH; SF3B1; NCSTN; RTF1; RBM14; SAP18; CTR9; S100A9; NOP2; HMGB1; HIST1H2BB; DHX9; C

Biotin

Polyclonal Antibody

WB

Affinity Purified

SSRP1 is strongly supported by BioGPS gene expression data to be expressed in OVCAR3

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 100%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

81kDa

Li, Y., (2007) J. Biol. Chem. 282 (10), 6936-6945

Wet Ice

709

SSRP1

SSRP1

Rabbit

FACT complex subunit SSRP1

NM_003146

SSSNEGDSDRDEKKRKQLKKAKMAKDRKSRKKPVEVKKGKDPNAPKRPMS

SSRP1