ST-CY14

ST-CY14 is an inhibitor for Nur77-PPARγ interaction with an EC50 of 3.15 μM, that binds to Nur77 (Kd=32 nM), blocks Nur77 from being ubiquitinated and degraded by PPARγ, reduces fatty acid uptake and mitochondrial respiration, and inhibits the transcription of CD36 and FABP4. ST-CY14 inhibits the proliferation and migration of cancer cell MCF7 and MDA-MB-231. ST-CY14 inhibits tumor growth and bone metastasis in mouse models[1].

12352209

Mitochondrial Metabolism; Nuclear Hormone Receptor 4A/NR4A

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Cancer

O=C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CS)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@](C)(CCCC=CCCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@]2(C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N

C139H237N57O31S2

3266.86

[1]Bian H, et al., In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy. Adv Sci (Weinh) . 2024 Jul;11 (26) :e2308435.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10873/

Peptides

No Development Reported