Stat2 (fosfo-Tyr690) Antilichaam

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

6773

P52630

NP_005410.1

Human

Stat2 (phospho-Tyr690) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y (p) -L-K) derived from Human Stat2.

Unconjugated

Primary Antibodies

Phospho-Specific , Inflammasomes

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

113 kDa

This antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.

Western Blot: 1:1000

STAT2

Signal transducer and activator of transcription 2, 113kDa

Homo sapiens

Fu X. Y, et al. Proc. Natl. Acad. Sci. U. S. A. 89:7840-7843 (1992) Yan R, et al. Nucleic Acids Res. 23:459-463 (1995) Fu X. Y. Cell 70:323-335 (1992) Sugiyama T, et al. FEBS Lett. 381:191-194 (1996)

P113, ISGF-3, STAT113, MAPKAPK1A, RSK1, P113, MGC59816

WB

4885615

Liquid