STAT3 Antilichaam

STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.

6774

P40763

NP_644805

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

STAT3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (100%), Chicken: (100%)

STAT3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

STAT3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 85 kDa

IgG

STAT3

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Signal transducer and activator of transcription 3 (acute-phase response factor)

Homo sapiens

Schaefer TS, Sanders LK, and Nathans D. Cooperative transcriptional activity of Jun and Stat3b, a short form of Stat3. Proc. Natl. Acad. Sci. USA 1995; 92:9097-101.

Leonard WJ and O'Shea JJ. Jaks and STATs: biological implications. Annu. Rev. Immunol. 1998; 16:293-322.

Schindler C and Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 1995; 64:621-51.

Rajan P. STATus and context within the mammalian nervous system. Mol. Med. 2011; 17:965-73

STAT3 Antibody: APRF, HIES, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor

ELISA, WB, IHC-P, IF

21618340

Liquid