STAT3 Antilichaam, KO gevalideerd

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

6774

P40763

Human, Mouse, Rat, Monkey

Recombinant fusion protein containing a sequence corresponding to amino acids 640-770 of human STAT3 (NP_644805.1) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Stem Cell, Transcription

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 90kDa

IgG

STAT3

293T

Signal transducer and activator of transcription 3 (acute-phase response factor)

Homo sapiens

STAT3 Antibody: APRF, HIES, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor

WB, IHC, IF

Liquid