STAU1 Antilichaam - N-terminal regio : HRP (ARP40537_T100-HRP)

Staufen, RNA binding protein, homolog 1 (Drosophila)

STAU, PPP1R150

6780

O95793

NP_059347

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human STAU1

STAU1 (Staufen) is a member of the family of double-stranded RNA (dsRNA) -binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. Staufen is a member of the family of double-stranded RNA (dsRNA) -binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.

LONRF1; GLRX3; ZMAT3; NXT1; SPRTN; MATR3; EIF4A3; NUP155; PRDX6; NPEPPS; DDX23; DDX21; AIFM1; INA; ATP6V0D1; SART1; RPL14; AP3D1; CPNE3; IQGAP1; PABPC4; EIF3D; EIF3B; EIF3A; PRKRA; KHSRP; IRS4; SLC25A11; SMC1A; PABPN1; DDX39B; TUBA1A; MOGS; YWHAZ; XPO1; V

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

STAU1 is strongly supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

63kDa

Kim, Y.K., (2005) Cell 120 (2), 195-208

Wet Ice

577

STAU1

STAU1

Rabbit

Double-stranded RNA-binding protein Staufen homolog 1

NM_017453

LSVGGQQFNGKGKTRQAAKHDAAAKALRILQNEPLPERLEVNGRESEEEN