Stigmalactam

Stigmalactam is an aristolactam-type alkaloid extracted from Orophea enterocarpa with anticancer effects. Stigmalactam induces apoptosis via the mitochondrial pathway, with the activation of caspase-3/9, and a decrease in mitochondrial membrane potential (MTP) . Stigmalactam exhibits antioxidant activity by decreasing ROS production. Stigmalactam can be used for liver and breast cancer research[1].

289499-72-5

12352005

Apoptosis; Caspase; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Cancer

O=C1NC2=CC3=CC=C(C=C3C4=C2C1=C(OC)C(OC)=C4OC)O

C18H15NO5

325.32

[1]Banjerdpongchai R, et al. Stigmalactam from Orophea enterocarpa induces human cancer cell apoptosis via a mitochondrial pathway. Asian Pac J Cancer Prev. 2014;15 (23) :10397-400.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16535/

Natural Products

No Development Reported