Stigmast-5-een-3-ol

Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity[1][2][3].

5779-62-4

12352211

Amylases; Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53; PARP

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Cancer; Endocrinology; Metabolic Disease

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC(CC4)O)=CC3)C

C29H50O

414.71

[1]Fernando IPS, et al. Apoptotic and antiproliferative effects of Stigmast-5-en-3-ol from Dendronephthya gigantea on human leukemia HL-60 and human breast cancer MCF-7 cells. Toxicol In Vitro. 2018 Oct;52:297-305. |[2]Brinda Bolar, et al. ISOLATION AND BIOLOGICAL EVALUATION OF (24R) STIGMAST 5-EN-3-OL FROM CASSIA FISTULA BARK.|[3]Dina A. Ghinmy, et al. INVESTIGATION OF ANTI-OBESITY ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE SEEDS, IN VIVO AND IN SILICO MODELS.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N12999/

Natural Products

No Development Reported

Bax; Bcl-xL; Caspase 9