STIL Antilichaam

This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V- (D) -J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

6491

Q15468

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 1218-1287 of human STIL (NP_003026.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Stem Cell

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 143kDa

IgG

WB: 1:500 - 1:2000

STIL

Jurkat

A-549

STIL centriolar assembly protein

Homo sapiens

MCPH7, SIL, SCL-interrupting locus protein, SCL/TAL1 interrupting locus, TAL-1-interrupting locus protein

WB

Liquid