STIM2 Antilichaam

STIM2 Antibody: In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER) -like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.

57620

Q9P246

NP_065911

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

STIM2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

STIM2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

STIM2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

STIM2

Cat. No. 1306 - Human Spleen Tissue Lysate

Cat. No. 10-901 - Human Spleen Tissue Slide

Stromal interaction molecule 2

Homo sapiens

2+

Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature2006; 441:179-85.

2+2+

Ca2+

STIM2 Antibody: KIAA1482, Stromal interaction molecule 2

ELISA, WB, IHC-P, IF

41349446

Liquid