STIM2 Antilichaam

STIM2 Antibody: In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER) -like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.

57620

Q9P246

NP_065911

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

STIM2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

STIM2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

STIM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

STIM2

Cat. No. 1306 - Human Spleen Tissue Lysate

Cat. No. 10-901 - Human Spleen Tissue Slide

Stromal interaction molecule 2

Homo sapiens

Ca2+

Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature2006; 441:179-85.

2+2+

Ca2+

STIM2 Antibody: KIAA1482, Stromal interaction molecule 2

ELISA, WB, IHC-P, IF

41349446

Liquid