STOX1 Antilichaam

STOX1 Antibody: STOX1 (Storkhead box 1), also known as PEE4 or C10orf24, is a winged-helix domain containing transcription factor believed to play a role in the differentiation of stem cells. As a DNA-binding protein, STOX1 exists as three alternatively spliced isoforms, designated A, B and C, all of which localize to either the cytoplasm or the nucleus. Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4), also known as gestational proteinuric hypertension. STOX1 was also found to be functionally involved in late-onset Alzheimer's disease.

219736

Q6ZVD7

NP_689922

Human

Unconjugated

Primary Antibodies

Stem Cell

STOX1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1304 - Human Liver Tissue Lysate

1 mg/mL

STOX1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

STOX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

STOX1 antibody is human reactive. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. STOX1 antibody recognize the two longest isoforms.

STOX1

Storkhead box 1

Homo sapiens

Van Dijk M, van Bezu J, Chim SS, et al. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. Nat. Genet. 2005; 37:514-9.

Kivinen K, Peterson H, Hiltunen L, et al. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Eur. J. Hum. Genet. 2007;15:494-7.

Van Dijk M, van Bezu J, van Abel D, et al. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. Hum Mol. Genet. 2010; 19:2658-67.

Van Abel D, Hölzel DR, Jain S, et al. SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells. PLoS One 2011; 6 :e21994.

STOX1 Antibody: PEE4, C10orf24, Storkhead-box protein 1, Winged-helix domain-containing protein

ELISA, WB

63025200

Liquid