Strogen Receiver 1 (ESR1) Muis monoklonaal antilichaam [Kloon ID: LBI5E11]

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Carrier-free (BSA/glycerol-free) ESR1 mouse monoclonal antibody, clone LBI5E11

ER; Era; ESR; ESRA; ESTRR; NR3A1

Homo sapiens estrogen receptor 1 (ESR1), transcript variant 1, mRNA.

2099

P03372

Unconjugated

WB 1:200~2000, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

ESR1

https://www.ncbi.nlm.nih.gov/gene/?term=2099

https://www.uniprot.org/uniprot/P03372