STUB1 Antilichaam - C-terminalgebied: HRP (ARP43059_P050-HRP)

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

CHIP, SCA48, UBOX1, SCAR16, HSPABP2, NY-CO-7, SDCCAG7

10273

Q9UNE7

NP_005852

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human STUB1

STUB1 modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. STUB1 mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.

HSP90AA1; HSPA8; PCSK9; OLFM3; ATCAY; CCL28; UBE2Q1; TXN2; RUSC1; HSPA1B; FMR1; ERN1; STUB1; UBE2V1; UBE2N; UBE2D3; UBE2D1; UBC; TP53; MAPT; MAP3K11; SNAI2; BAG1; HSPA4L; CDC37; DNAJB6; BAG2; BAG3; BAG4; MLF2; HSP90AB1; HSPA4; HSPA2; HSPA1L; ENDOG; TXLNG

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

35kDa

Parsons, J.L., (2008) Mol. Cell 29 (4), 477-487

Wet Ice

303

STUB1

STUB1

Rabbit

E3 ubiquitin-protein ligase CHIP

NM_005861

VDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHF