STX107
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
STX107 is a metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator (NAM) with a pKi of 8.32. STX107 inhibits glutamate-induced Ca2+ mobilization, IP1 accumulation, and ERK1/2 phosphorylation. STX107 also inhibits glutamate-induced mGlu5 internalization[1].
935685-90-8
12352005
H302-H315-H319-H335
ERK; mGluR
GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt
Neurological Disease
N#CC1=CC(F)=CC(C2=NC=C(C=C2)C#CC3=CSC(C)=N3)=C1
C18H10FN3S
319.36
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Arsova A, et al. Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5. Mol Pharmacol. 2020 Jul;98 (1) :49-60.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W565924/
Reference compound1
No Development Reported
MGluR5
Beschrijving
STX107 is a metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator (NAM) with a pKi of 8.32. STX107 inhibits glutamate-induced Ca2+ mobilizatio
Specificaties
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MS Solution sufficient for 400 Mini, 142 Midi, 33 Maxi
MS10
Each
MS pipette, variable vol µme 10~100 µL
MSP-100
1 Unit
MS 12-ch pipette, variable vol µme 20~200 µL
MSP-12X200
1 Unit
MS 12-ch pipette, variable vol µme 2~20 µL
MSP-12X20
1 Unit
MS Rocking anti-moistured shaker with 30 x 30 cm platform and flat non-slip rubber mat
MS-NRK-3001
1 Unit
MS Orbital Shaker with 30 x 30 cm platform and flat non-slip rubber mat
MS-NOR-30
1 Unit
MS Reciprocal anti-moistured shaker with 30 x 30 cm platform and flat non-slip rubber mat
MS-NRC-3001
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MS pipette, variable vol µme 1000~10000 µL
MSP-10000
1 Unit