SU9516
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 µM for cdk2, cdk1, cdk4, cdk9 respectively.1,2 Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis.3 Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death.4 Inhibits epithelial-mesenchymal transition (IC50=1.21 µM) a crucial pathological event in tumor cell budding and metastasis.5 Cell permeable.
Unconjugated
Orange solid
-20°C
Beschrijving
SU9516 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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