SUD3 Antilichaam

Little is known of the function of the sushi domain containing 3 protein (SUSD3), but its expression has been reported in estrogen receptor-alpha (ERalpha) -positive breast tumors with decreased expression reported in aggressive malignant tumors (1,2) . Recently, SUSD3 has been found to promote estrogen-dependent cell proliferation and may regulate cell-cell and cell-substrate interactions and migration in breast cancer (3) . Furthermore, elevated SUSD3 mRNA levels were observed in aromatase inhibitor-responsive breast tumors, suggesting that it may also serve as a novel predictor of response to endocrine therapy and a potential therapeutic target (3) .

203328

Q96L08

NP_659443

Human, Mouse

Unconjugated

Primary Antibodies

Cell Cycle, Cancer

SUSD3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

1 mg/mL

SUSD3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SUSD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SUSD3 antibody is human and mouse reactive. Multiple isoforms of SUSD3 are known to exist.

SUSD3

Cat. No. 17-201 - 3T3/BALB Cell Slide

Sushi domain containing 3

Homo sapiens

Abba MC, Hu Y, Sun H, et al. Gene expression signature of estrogen receptor alpha status in breast cancer. BMC Genomics 2005; 6:37.

Parris TZ, Danielsson A, Nemes S, et al. Clinical implications of gene dosage and gene expression patterns in diploid breast cancer. Clin. Cancer Res. 2010; 16:3860-74.

Moy I, Todorovic V, Dubash AD, et al. Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells. Oncogene 2015; 34:323-33.

Sushi domain containing 3

ELISA, WB, ICC

21450717

Liquid