Sulforafeen (standaard)

Sulforaphene, isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10-4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals[1][2][3][4].

592-95-0

12352211

Apoptosis; EGFR; ERK; Microtubule/Tubulin; NF-κB

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Cancer

O=S(/C=C/CCN=C=S)C

C6H9NOS2

175.27

[1]Kuang P, et al. Separation and purification of sulforaphene from radish seeds using macroporous resin and preparative high-performance liquid chromatography. Food Chem. 2013 Jan 15;136 (2) :342-7.|[2]Anita M. Brinker, et al. Herbicidal activity of sulforaphene from stock (Matthiola incana) . Journal of Chemical Ecology. Vol. 19. No. 10, 1993.|[3]Mondal A, et al. Sulforaphene promotes Bax/Bcl2, MAPK-dependent human gastric cancer AGS cells apoptosis and inhibits migration via EGFR, p-ERK1/2 down-regulation. General Physiology and Biophysics, 27 Nov 2015, 35 (1) :25-34.|[4]Ren K, et al. Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway. J Biochem Mol Toxicol. 2017 Aug;31 (8) .|[5]Bao C, et al. Sulforaphene Interferes with Human Breast Cancer Cell Migration and Invasion through Inhibition of Hedgehog Signaling. J Agric Food Chem. 2016 Jul 13;64 (27) :5515-24.|[6]Byun S, et al. Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization. Mol Nutr Food Res. 2016 May;60 (5) :1068-78.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N2450R/

Reference Standards